Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice
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چکیده
منابع مشابه
Impaired induction of type II interferon in tumor-bearing mice.
The response of mice to type II interferon inducers such as purified protein derivative of tuberculin or OK-432 was significantly impaired after either the implantation of tumor cells or the injection of cell-free tumor ascitic fluids. Complete inhibition of type II interferon induction occurred in 3 to 5 days. This inhibitory effect persisted until the death of mice implanted with tumors or fo...
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Protein synthesis has been measured in vivo in liver and muscle of mice bearing the XK1 tumor, an appropriate model for cancer cachexia. Two different methods were used involving measurement of tracer incorporation into tissue protein either at the end of a 4-hr constant infusion of [14C]tyrosine or 10 min after i.v. injection of a flooding dose of [3H]phenylalanine. Whole-body tyrosine flux wa...
متن کاملEffect of thio TEPA on the synthesis of protein and nucleic acids in tumor-bearing mice.
Treatment with three daily doses (3-10 gg/gm each) of thioTEPA inhibited incorporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-1 mouse tumor in a majority of experiments. In tumors from mice having other treatment schedules and in livers from all groups no definite change ...
متن کاملEffect of chlorambucil on synthesis of protein and nucleic acids in tumor-bearing mice.
1. Following the treatment with three doses (8-16 Mg/gm each) of chlorambucil, in corporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-l mouse tumor was inhibited in a majority of the experiments. 2. In tumors from mice of the group treated with one dose and in livers from ...
متن کاملProtein synthesis in liver and skeletal muscle of mice bearing an ascites tumor.
In mice bearing an ascites tumor at an advanced stage of growth, the weight of the gastrocnemius muscle fell, whereas that of the liver increased. Fractional rates of protein synthesis were measured in vivo under conditions designed to minimize uncertainties in the determination of the specific radioactivity of the precursor amino acid pool. Protein synthesis in liver increased in the tumor-bea...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0226440